This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology. Based on the 2009 proceedings of the 37th annual ISOTT conference, this volume covers all aspects of oxygen delivery to tissue, everything from near infrared spectroscopy, tumor biology, angiogenesis and mitochondrial metabolism to systems modeling, gas transport, hypoxic adaptation and exercise physiology. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biological bases for pathology related to tissue oxygenation. This multidisciplinary volume includes contributions from scientists, engineers, clinicians and mathematicians and is aimed and students and experts from a range of research fields.