Salient Features: This is the best one among all monographs on Platelets, put together by Professor Gundu HR Rao. There is the description of the roles of the cells in hemostasis and thrombosis at an extended level. Platelet story has been narrated with beautiful electron photomicrographs and original illustrations. This monograph includes discussions on aspirin resistance, unique mechanism of platelet membrane modulation, platelet interactions with vascular surfaces, biomaterials, and biomedical devices, etc. Furthermore, the book includes over 1000 references related to our work at the University of Minnesota (1970-2015). The monograph provides a comprehensive overview of the work done at the Thrombosis Research Laboratory, Lillehei Heart Institute, University of Minnesota, USA for over four decades by Professor (Late) James G White and Dr Gundu HR Rao. The monograph includes chapters on ultrastructure morphology, platelet dysfunction, platelet physiology, platelet activation mechanisms, role of calcium in platelet activation, role of eicosanoids, cAMP and cGMP, antiplatelet drugs, antiplatelet therapies, aspirin resistance, platelet dysfunction in diabetes, platelet membrane modulation, platelet vessel-wall interactions, and blood biocompatibility. Authors hope that this collective work on Platelet Physiology and Pharmacology will serve the students, clinicians, and researchers as a useful reference monograph.