Owen wakes up in the Montana Territory tied to a wooden pole in the middle of a Blackfoot Village. He doesn't remember his name, where he came from, or anything about his past. The Blackfoot Confederacy thinks that a book that was lying beside him when he was captured has spiritual powers because he held it up during the two-day battle when they killed all the others in his large wagon train. Owen is restored to health, but a Blackfoot chief named Askuwheteau forces him to play a game called "the Chase Game" to see if the book he carried with him has spiritual powers. If Owen survives this game, which no captive or warrior has before, it will prove the book they call "Big Medicine" has spiritual powers and his life will be spared. If he loses the game, he will die and they will destroy the book. Can he outlast the twelve-armed Blackfoot warriors with just the arrow he pulled out of the ground to start the Chase Game? At the same time, a white woman held by Chief Askuwheteau since her childhood had prayed to God every day to send someone to rescue her and take her back to her own people. Just when she thought her prayers had been answered, a Blackfoot warrior, named Megedagik, traded ten Appaloosas for her and took her away to be his squaw. Had God forgotten her? Had He always planned on her living among the Blackfoot Indians? In another part of the Montana Territory, hostile Indians besiege Fort Pennington. Supplies and ammunition are running low while the soldiers and settlers inside the Fort fight two Indian tribes for their lives. Their survival depends on a dispatch rider getting through to Fort Shaw, a scruffy old mountain man named Hobbs, and a miracle from God. Do the soldiers and settlers within Fort Pennington survive? Will "Big Medicine" influence their future?