The use of probiotics has re-emerged as a means to restore and boost the beneficial microbes in human and animal gut. The resurgence of interest in probiotics has been accompanied by many review papers by different definitions. The joint expert panel of the Food and Agriculture Organization of the United Nations and the World Health Organization defines probiotics as live microorganisms and they confer a health benefit on the host. The role of probiotics and prebiotics will likely increase in the future as evidence accrues from well conducted studies on the efficacy of these agents when used in standardized formulations. The potential for probiotics, prebiotics and synbiotics to be used as an adjunct in the control of antibiotic resistance is particularly appealing. It is believed that modulation of the normal microflora to benefit the host can be achieved through the use of prebiotics, probiotics and synbiotics.