Protein Bioinformatics is a book which introduces the concept of protein bioinformatics and it covers the topics such as structure databases and biological databases in the first half of this book. This book provides a comprehensive analysis of the protein structure and further prediction in the protein structure. The aim of this book is to describe hybrid methods that have been developed in order to solve the problem related to the protein structure prediction. In second half of this book, the readers are provided with the details regarding two models such as Machine Learning Models and Mathematical Methods. The book highlights Data Mining which is done in Protein Bioinformatics so as to extract information from large datasets and further briefs about Intelligent Mining.