Irina and her renegade variant friends are scrambling to pick up the trail of their former employer, Ivan, and his globally catastrophic scheme. After strategically sharing their story with the media, the group heads south from Vancouver to Seattle hoping to recruit more experienced-and lethal-variants to their cause.

Their attention develops a laser focus on an engineered disaster mere days ahead of them. Ivan is using what staff and resources remain of Innoviro Industries to set off a violent earthquake in San Francisco. While they fight to stop the earthquake, Irina pushes the love of her life Jonah as far away as she can, trying to keep his unstable genetic degradation in check.

Irina's friends think they've seen the worst that Innoviro could bring forth by the time they reach a secret facility in the Mojave Desert. As they near the property, the group uncovers a horror none of them had ever imagined.