This two volume set, LNAI 16748 and 16749, constitutes the refereed proceedings of the 24th International Conference on Artificial Intelligence in Medicine, AIME 2026, held in Ottawa, ON, Canada, during July 7-10, 2026.

Bringing together cutting-edge research from a global community of scholars and practitioners, the proceedings reflect a competitive selection process, with 30 full papers, 21 short papers, and 82 poster and demo papers selected from 236 submissions spanning 53 countries. The contributions cover a broad spectrum of topics categorized into two thematic pillars: AI Foundations and Methodological Innovations - encompassing Learning Paradigms and Representational Advances; Knowledge, Reasoning, and Semantic Integration; and Language, Imaging, and Signal Intelligence. Applications, Systems, and Health Impact - covering Clinical AI and Decision Support Systems; Deployment, Evaluation, and Governance; and Patient-Centred and Population-Level Applications.